. Author manuscript; available in PMC: 2021 Jun 2.

Published in final edited form as: J Alzheimers Dis. 2021;80(3):1269–1279. doi: 10.3233/JAD-200998

Table 4.

Association between elevated depressive symptoms and brain volume

MRI outcome measure	Model 1^*			Model 2^**			p for interaction term between APOE4 status and elevated depressive symptoms
MRI outcome measure	B	SE	p	B	SE	p
Total cerebral brain volume	−5.836	6.194	0.346	−5.050	6.315	0.424	0.322
Frontal lobe brain volume^a	< 0.001	< 0.001	0.818	< 0.001	< 0.001	0.852	0.472
Temporal lobe brain volume^a	0.001	< 0.001	0.027	< 0.001	< 0.001	0.112	0.827
Hippocampal brain volume^a	< 0.001	< 0.001	0.142	< 0.001	< 0.001	0.249	0.509
Left hippocampal brain volume^a	< 0.001	< 0.001	0.092	< 0.001	< 0.001	0.161	0.237
Right hippocampal brain volume^a	< 0.001	< 0.001	0.279	< 0.001	< 0.001	0.445	0.944
White matter hyperintensity volume	0.004	0.166	0.978	0.086	0.168	0.605	0.805
	Model 1^*			Model 2^**
	C-statistic	OR (95% CI)	p	C-statistic	OR (95% CI)	p
Extensive white matter hyperintensity volume (yes versus no)	0.593	1.310 (0.823–2.083)	0.254	0.635	1.137 (0.700–1.846)	0.603

Expressed as a percentage of total cerebrum cranial volume.

Adjusted for age, sex, education, and time between CES-D and MRI.

^**

Additional adjustments for hypertension, history of diabetes, current smoking, any alcohol use, history of cardiovascular disease, and APOE4 status. Two-sided significance set at p < 0.01.