Fig. 12.

Combinatorial code of transcriptional networks reveals the complexity of development. (A) A schematic outlining the summary of events that take place when Toy is removed simultaneously with either NURF or Pnt. (B) Schematic illustrating how the removal of multiple transcriptional networks reveals developmental choices that are not predicted by the knockdown of individual factors. (C) Our data indicates that a hidden step in the development of the eye-antennal disc is the choice between the fate of the head epidermis and antenna. We suggest that Toy and NURF work on independent gene targets to promote the fate of the head epidermis. NURF appears to directly regulate pnt but the targets of Toy are yet to be identified.