TABLE 3.

Prenatal diagnosis and pregnancy outcomes of 378 NIPS test failures (excluding lost-to-follow-up cases).

Characteristic	n	Proportion (%)	Remarks
Performed invasive prenatal diagnosis	135	35.71
Abnormal chromosomal results	14	3.70
Normal chromosomal results	121	32.01
Normal pregnancy outcomes	116	30.69
Abnormal pregnancy outcomes	5	1.32
Abnormal development after birth	2	0.53	See Table 4. Case numbers S1, S2
Premature delivery	1	0.26	Died after giving birth prematurely at 28 week
Miscarriage	2	0.53	No abortion tissue examination was performed
Rejected invasive prenatal diagnosis	243	64.29
Normal pregnancy outcomes	210	55.56
Abnormal pregnancy outcomes	33	8.73
Abnormal development after birth	3	0.79	See Table 4. Case numbers S4, S5, and S6
Premature delivery	2	0.53	One subject died 2 months after birth from pulmonary dysplasia, one subject died after preterm birth at 27 + 2 weeks
Miscarriage	13	3.44	Only two cases underwent abortion tissue examinations, and the results were normal. The reasons for the rest cases are unknown
Induced labor	15	3.97	Five cases had prenatal ultrasound malformation or other abnormalities, two cases had stillbirth, three cases had serious pregnancy complications, and five cases had unknown causes