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. 2021 May 19;12:676181. doi: 10.3389/fimmu.2021.676181

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Copyright © 2021 Hosseinkhani, Derakhshani, Shadbad, Argentiero, Racanelli, Kazemi, Mokhtarzadeh, Brunetti, Silvestris and Baradaran

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Blocking the interaction between VISTA and VISTA-R can lead to T cell activation and the upregulation of IFN-γ, IL-2, IL-17, CXCL-11, CCL-3, and CCL-5. VISTA, V-domain Ig suppressor of T cell activation; VISTA-R, VISTA-receptor.