Figure 2.

MSC-EXs (EX) containing miR-145-5p improved functional recovery and reduced histopathological injury in SCI rats

(a) The BBB score was used to evaluate the hind limb function recovery of rats. (b) The rat spinal cord tissue was collected 28 days after the operation for HE staining and histopathological observation. (c) The rat spinal cord tissue was collected 28 days after the operation for Nissl staining. ELISA was used to detect the expressions of inflammatory factors TNF-α (d), IL-1β (E) and IL-6 (f) in spinal cord tissue, and to explore the effect of MSC-EXs on the inflammation of SCI rats. (n = 3, ***P < 0.001, vs. Sham group; ^###P < 0.001, vs. Model+EX-miR-NC group; ^{^^}P < 0.01, ^{^^^}P < 0.001, vs. Model+PBS group)