Figure 3.
Association between ALOX5AP expression and clinicopathologic characteristics. Comparison of ALOX5AP expression in different clinical conditions including: (A) lymphatic invasion, (B) tumor residual, (C) primary therapy outcome and (D) platinum response. (E) Receiver operating characteristic (ROC) curve was drawn to analyze the predictive value of ALOX5AP for platinum-containing chemotherapy responsiveness. (F) The gene effect of ALOX5AP on cisplatin responsiveness of ovarian adenocarcinoma cell lines. Kaplan Meier curves of SOC patients receipt of platinum-based chemotherapy with high or low ALOX5AP expression in (G) pooled SOC patient cohorts, (H) TCGA-OV cohort, and (I) stage 3-4 SOC patient cohorts. (NRD, no residual disease; RD, residual disease; CR, complete response; PR, partial response).