TABLE A1.
Search strategy
| Database/consultation date | # | Concept | Search strategy | Results | Combination of concepts | |
|---|---|---|---|---|---|---|
| # | Total | |||||
| PubMed/20200611 | #1 | Participant =Pregnancy | Pregnan*[TIAB] OR Gestation[TIAB] OR Fetus*[TIAB] OR “Fetal Structures” [TIAB] OR “Fetal Structure”[TIAB] OR “Fetal Tissue”[TIAB] OR “Fetal Tissues”[TIAB] OR “Pregnancy”[MeSH] OR “Pregnant Women”[MeSH] OR Fetus[MeSH] | 1,110,096 |
#1 AND #2 AND #3 AND #4 |
2,034 |
| #2 | Index test = Non‐invasive prenatal test | “Non‐invasive prenatal test”[TIAB] OR NIPT[TIAB] OR “Cell Free Nucleic Acid”[TIAB] OR “Circulating Nucleic Acids”[TIAB] OR “Cell Free DNA”[TIAB] OR cfDNA[TIAB] OR cirDNA[TIAB] OR “Cell Free Deoxyribonucleic Acid”[TIAB] OR “Circulating DNA”[TIAB] OR “Cell Free RNA”[TIAB] OR cfRNA[TIAB] OR cirRNA[TIAB] OR “Cell Free Ribonucleic Acid”[TIAB] OR “Circulating RNA”[TIAB] OR “Prenatal Diagnosis”[TIAB] OR “Prenatal Diagnoses”[TIAB] OR “Intrauterine Diagnosis”[TIAB] OR “Intrauterine Diagnoses”[TIAB] OR “Antenatal Diagnosis”[TIAB] OR “Antenatal Diagnoses”[TIAB] OR “Prenatal Screening”[TIAB] OR “Antenatal Screening”[TIAB] OR “Prenatal Diagnosis”[MeSH] OR “Cell‐Free Nucleic Acids”[MeSH] | 88,361 | |||
| #3 | Outcome 1 = Test accuracy | "test accuracy"[TIAB] OR sensitivity[TIAB] OR specificity[TIAB] OR “positive predictive value”[TIAB] OR “negative predictive value”[TIAB] OR “sensitivity and specificity”[MeSH] OR “Predictive Value of the Test”[TIAB] | 1,436,981 | |||
| #4 | Outcome 2 = Chromosome Disorders | “Chromosome Disorder”[TIAB] OR “Chromosome Disorders”[TIAB] OR “Chromosomal Disorder”[TIAB] OR “Chromosome Disorders”[TIAB] OR “Chromosome Aberration”[TIAB] OR “Chromosome Aberrations”[TIAB] OR “Chromosomal Aberration”[TIAB] OR “Chromosomal Aberrations”[TIAB] OR “Chromosome Abnormality”[TIAB] OR “Chromosome Abnormalities”[TIAB] OR “Chromosomal Abnormality”[TIAB] OR “Chromosomal Abnormalities”[TIAB] OR “Cytogenetic Abnormality”[TIAB] OR “Cytogenetic Abnormalities”[TIAB] OR “Cytogenetic Aberration”[TIAB] OR “Cytogenetic Aberrations”[TIAB] OR “Autosome Abnormality”[TIAB] OR “Autosome Abnormalities”[TIAB] OR Aneuploid*[TIAB] OR “chromosome imbalance”[TIAB] OR “chromosomal imbalance”[TIAB] OR "Chromosome Disorders"[MeSH] OR “Chromosome Aberrations”[MeSH] OR Aneuploidy[MeSH] | 216,262 | |||
| Embase/20200611 | #1 | Participant =Pregnancy | Pregnan*:ti,ab OR Gestation:ti,ab OR Fetus*:ti,ab OR “Fetal Structure*”:ti,ab OR “Fetal Tissue*”:ti,ab OR “pregnancy”/exp OR “pregnant woman”/exp OR Fetus/exp | 1,224,399 |
#1 AND #2 AND #3 AND #4 |
1,919 |
| #2 | Index test = Non‐invasive prenatal test | “Non‐invasive prenatal test*”:ti,ab OR NIPT:ti,ab OR “Cell Free Nucleic Acid*”:ti,ab OR “Circulating Nucleic Acid*”:ti,ab OR “Cell Free DNA”:ti,ab OR cfDNA:ti,ab OR cirDNA:ti,ab OR “Cell Free Deoxyribonucleic Acid”:ti,ab OR “Circulating DNA”:ti,ab OR “Cell Free RNA”:ti,ab OR cfRNA:ti,ab OR cirRNA:ti,ab OR “Cell Free Ribonucleic Acid”:ti,ab OR “Circulating RNA”:ti,ab OR “Prenatal Diagnos*”:ti,ab OR “Intrauterine Diagnos*”:ti,ab OR “Antenatal Diagnos*”:ti,ab OR “Prenatal Screening”:ti,ab OR “Antenatal Screening”:ti,ab OR “Prenatal Diagnosis”/exp OR “Cell‐Free Nucleic Acids”/exp | 129,350 | |||
| #3 | Outcome 1 = Test accuracy | “test accuracy”:ti,ab OR sensitivity:ti,ab OR specificity:ti,ab OR “positive predictive value*”:ti,ab OR “negative predictive value*”:ti,ab OR “predictive value of test*”:ti,ab OR “sensitivity and specificity”/exp OR “predictive value”/exp | 1,551,179 | |||
| #4 | Outcome 2 = Chromosome Disorders | “Chromosom* Disorder*”:ti,ab OR “Chromosom* Aberration*”:ti,ab OR “Chromosom* Abnormalit*”:ti,ab OR “Cytogenetic Abnormalit*”:ti,ab OR “Cytogenetic Aberration*”:ti,ab OR “Autosome Abnormalit*”:ti,ab OR Aneuploid*:ti,ab OR “chromosom* imbalance”:ti,ab OR “Chromosome Disorders”/exp OR “Chromosome Aberrations”/exp OR Aneuploidy/exp | 255,660 | |||
| Cochrane Library/20200611 | #1 | Participant =Pregnancy | (Pregnan*):ti,ab,kw OR (Gestation):ti,ab,kw OR (Fetus*):ti,ab,kw OR (“Fetal Structure*”):ti,ab,kw OR (“Fetal Tissue*”):ti,ab,kw OR [mh “pregnancy”] OR [mh “pregnant woman”] OR [mh “Fetus”] | 66,902 |
#1 AND #2 AND #3 AND #4 |
23 |
| #3 | Index test = Non‐invasive prenatal test | (“Non‐invasive prenatal test*”):ti,ab,kw OR (NIPT):ti,ab,kw OR (“Cell Free Nucleic Acid*”):ti,ab,kw OR (“Circulating Nucleic Acid*”):ti,ab,kw OR (“Cell Free DNA”):ti,ab,kw OR (cfDNA):ti,ab,kw OR (cirDNA):ti,ab,kw OR (“Cell Free Deoxyribonucleic Acid*”):ti,ab,kw OR (“Circulating DNA”):ti,ab,kw OR (“Cell Free RNA”):ti,ab,kw OR (cfRNA):ti,ab,kw OR (cirRNA):ti,ab,kw OR (“Cell Free Ribonucleic Acid*”):ti,ab,kw OR (“Circulating RNA”):ti,ab,kw OR (“Prenatal Diagnos*”):ti,ab,kw OR (“Intrauterine Diagnos*”):ti,ab,kw OR (“Antenatal Diagnos*”):ti,ab,kw OR (“Prenatal Screening”):ti,ab,kw OR (“Antenatal Screening”):ti,ab,kw OR [mh “Prenatal Diagnosis”] OR [mh “Cell‐Free Nucleic Acids”] | 1,028 | |||
| #5 | Outcome 1 = Test accuracy | (“test accuracy”):ti,ab,kw OR (sensitivity):ti,ab,kw OR (specificity):ti,ab,kw OR (“positive predictive value”):ti,ab,kw OR (“negative predictive value”):ti,ab,kw OR (“predictive value of tests”):ti,ab,kw OR [mh “sensitivity and specificity”] OR [mh “predictive value”] | 65,443 | |||
| #7 | Outcome 2 = Chromosome Disorders | (“Chromosom* Disorder*”):ti,ab,kw OR (“Chromosom* Aberration*”):ti,ab,kw OR (“Chromosom* Abnormalit*”):ti,ab,kw OR (“Cytogenetic Abnormalit*”):ti,ab,kw OR (“Cytogenetic Aberration*”):ti,ab,kw OR (“Autosome Abnormalit*”):ti,ab,kw OR (Aneuploid*):ti,ab,kw OR (“chromosom* imbalance”):ti,ab,kw OR [mh “Chromosome Disorders”] OR [mh “Chromosome Aberrations”] OR [mh “Aneuploidy”] | 1,625 | |||
| Web of Sciences/20200611 | #1 | Participant =Pregnancy | TS=(Pregnan* OR Gestation OR Fetus* OR “Fetal Structure*” OR “Fetal Tissue*”) | 1,070,478 |
#1 AND #2 AND #3 AND #4 |
337 |
| #2 | Index test =Non‐invasive prenatal test | TS=(“Non‐invasive prenatal test” OR NIPT OR “Cell Free Nucleic Acid*” OR “Circulating Nucleic Acid*” OR Cell “Free DNA OR cfDNA” OR cirDNA OR “Cell Free Deoxyribonucleic Acid*” OR “Circulating DNA OR Cell Free RNA” OR cfRNA OR cirRNA OR “Cell Free Ribonucleic Acid*” OR “Circulating RNA OR Prenatal Diagnos*” OR “Intrauterine Diagnos*” OR “Antenatal Diagnos*” OR “Prenatal Screening” OR “Antenatal Screening”) | 9,049 | |||
| #3 | Outcome 1 = Test accuracy | TS=(“test accuracy” OR sensitivity OR specificity OR “positive predictive value*” OR “negative predictive value*” OR “predictive value of tests”) | 1,858,994 | |||
| #4 | Outcome 2 = Chromosome Disorders | Ts=(“Chromosom* Disorder*” OR “Chromosom* Aberration*” OR “Chromosom* Abnormalit*” OR “Cytogenetic Abnormalit*” OR “Cytogenetic Aberration*” OR “Autosome Abnormalit*” OR Aneuploid* OR “chromosom* imbalance”) | 107,251 |