Figure 5.

Specific T-cell response of PBMCs from rhesus macaques immunized with Sad23L-nCoV-S and Ad49L-nCoV-S vaccines or sham controls by prime-boost vaccination regimen. (A–C) IFN-γ or (D–F) IL-2 secreting T-cell response (SFCs/million cells) to S peptides, S or RBD protein was measured by ELISpot. (G–J) Frequency of intracellular IFN-γ expressing CD4⁺/CD8⁺ T-cell response to S peptides was determined by ICS, respectively. Data are shown as mean ± SEM. P-values are calculated with two-tailed t test. Statistically significant differences are shown with asterisks (*, P < 0.05; **, P < 0.01 and ***, P < 0.001).