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. 2021 May 13;9:652970. doi: 10.3389/fbioe.2021.652970

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Copyright © 2021 Sandonà, Di Pietro, Esposito, Ventura, Silini, Parolini and Saccone.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Therapeutic properties of mesenchymal stromal cells (MSCs) and their secretome [soluble factors and extracellular vesicles (EVs)] in various muscle injury models. MSCs derived from different tissues participate in skeletal muscle tissue regeneration, directly or through their secretome (soluble factors and EVs). The cartoon reports the bioactive fraction of the MSC secretome (cytokines, miRs, and growth factors) and the main regenerative processes induced by these factors, as discussed in the main text (↑, upregulation/induction; ↓, downregulation/inhibition). The schematic art pieces used in this figure were provided by Servier Medical art (https://smart.servier.com). Servier Medical Art by Servier is licensed under a Creative Commons Attribution 3.0 Unported License.