Table 2.
Selected drug information of current ongoing clinical studies on SARS-CoV-2.
Drug name | Mechanism of action | Indication | DrugBank ID |
---|---|---|---|
Remdesivir | RNA polymerase inhibitor | Anti-Ebola passed phase III, COVID-19 phase III | DB14761 |
Lopinavir | Protease inhibitor | Anti-HIV approved, COVID-19 | DB01601 |
Ritonavir | Protease inhibitor | Anti-HIV approved, COVID-19 | DB00503 |
Emtricitabine | Nucleoside reverse transcriptase inhibitor | Anti-HIV approved, anti-HBV | DB00879 |
Tenofovir | Nucleoside reverse transcriptase inhibitor | Anti-HIV phase III, anti-HBV | DB14126 |
Ribavirin | Viral mRNA and protein synthesis inhibitor | Anti-HCV, anti-HBV, anti-SARS, anti-influenza, COVID-19 | DB00811 |
Methylprednisolone | Corticosteroid | COVID-19 phase II, allergic asthma and rheumatic disorders approved | DB00959 |
Oseltamivir | Neuraminidase inhibitor; sialidase inhibitor | Anti-influenza approved, COVID-19 phase III | DB00198 |
Danoprevir | Protease inhibitor | Anti-HCV phase III, COVID-19 phase 4 | DB11779 |
Chloroquine | — | Antimalarial approved, anti-HIV phase III, anti-HCV, COVID-19 phase 4 | DB14761 |