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. 2020 Oct 2;101(2):177–192. doi: 10.1038/s41374-020-00490-5

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© The Authors 2020, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Schematic and (b) RPPA heat map data showing increased pMEK^S127, pERK^T202/Y204, pAKT^T308, and decreased expression of pAKT^S273 in lysates from WT, cKras^Mod, and cKras^High pancreata. c Quantification of RPPA relative expression data. d IHC analysis of pAKT^T308 and pERK^T202/Y204 in WT, cKras^Mod and cKras^High pancreata confirms RPPA data that pAKT^T308 and pERK^T202/Y204 are significantly increased in cKras^Mod and cKras^High pancreata relative to cKras^Low. e Western blot analysis of downstream signaling pathways in WT, cKras^Low, cKras^Mod, and cKras^High cultured pancreatic ducts. f Quantification of western blot data normalized to vinculin. g Heatmap and (h) quantification for PTEN relative expression in WT, cKras^Mod, and cKras^High mice. (i) IHC staining for PTEN of pancreata from cKras^Low, cKras^Mod, and cKras^High mice (Zoomed in ×40 magnification images in inset). PTEN expression in normal ducts can be seen in cKras^Low, cKras^Mod, and cKras^High mice. Scale bars are 50 µM.