Table 1:

Frequency of selected genomic alterations among biliary tract cancer subtypes

Gene	IHCCA	EHCCA	GBC
ARID1A	18–23%	12%	13%
BAP1	8–19%	0–12%	0–2%
BRAF	5%	3%	1%
CDKN2A/B	27%	17%	19%
EGFR	1–4%	0–1%	4–18%
ERBB2	3%	11%	16%
FGFR1–3	4–13%	0%	3%
IDH1/2	20–29%	0–5%	0%
KRAS	7–25%	12–42%	0–11%
MET	2%	0%	1%
PI3KCA	5%	7%	14%
SMAD4	5%	30%	N/A
STK11	1%	11%	N/A
TP53	18–27%	40–49%	59%

Table 1: This table depicts selected genomic alterations across biliary tract cancer subtypes when stratified by anatomic location. These data were extracted from Javle et al. Cancer 2016, Lowery et al. Clinical Cancer Research 2018, and Nakamura et al. Nature Genetics 2015 [1,3,4].

IHCCA, intrahepatic cholangiocarcinoma; EHCCA, extrahepatic cholangiocarcinoma; GBC, gallbladder cancer.