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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Dev Biol. 2021 Mar 26;476:137–147. doi: 10.1016/j.ydbio.2021.03.019

Figure 3: Sustained MEK/MAPK activity in the LGE of Gsx2e-Cre;RosaMEK1DD/+ embryos.

Figure 3:

Representative images at E15.5 from controls (A, C, E, G) and double transgenic Gsx2e-Cre;RosaMEK1DD/+ (called MEK/MAPK GOF) embryos (B, D, F, and H). MEK/MAPK GOF embryos show increased p-ERK1/2 (B) and Etv5 (D) staining in the LGE ventricular zone compared to controls (A,C). NISSL staining shows abnormal morphology at the LGE sulcus (arrows in E-F), LGE, striatum, and forming axon tracts in the ventral telencephalon of MEK/MAPK GOF embryos (F,H) compared to controls (E,G). Scale bars in: B= 100μM for images in A-B, D= 200μM for images in C-D, F=200μM for images E-H. LGE= lateral ganglionic eminence, IC=internal capsule