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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Mol Cancer Ther. 2021 Mar 30;20(6):1092–1101. doi: 10.1158/1535-7163.MCT-20-0826

Figure 4. Inhibiting HOTAIR and DNMT blocks ovarian tumor initiation.

Figure 4.

A) Xenograft tumor growth curve of different treatment groups. OVCAR3 sorted ALDH+ cells were treated with guadecitabine alone or with PNA3. 5,000 cells were injected s.c. into mice. B) Images of tumors collected at end of study. C) Quantification of tumor-formation in mice. D) Stem cell frequency estimates were calculated using Extreme Limiting Dilution Assay software.