Table 1:

Demographic features for pet dogs enrolled in the Standard of Care (SOC) or Standard of Care + adjuvant sirolimus (SOC + S) clinical trial arms. ALP refers to total serum alkaline phosphatase activity, indicated as normal or elevated based upon each COTC institution’s clinical pathology laboratory reference interval.

	SOC	SOC + S
Intent to treat population	157	152
Age in years (Median, range)	8.3 (1.4 – 15.6)	7.9 (1.5 – 13)
Weight (kg) (Median, range)	38.8 (25 - 94.5)	39.0 (21.1 – 75.8)
Sex
Castrated Male	83 (53%)	90 (59%)
Spayed Female	64 (41%)	55 (36%)
Intact Male	7 (4.5%)	6 (4%)
Intact Female	3 (1.5%)	1 (1%)
ALP Status
Normal	118 (75%)	117 (77%)
Elevated	39 (25%)	35 (23%)
Tumor Location
Proximal humerus	33 (21%)	30 (20%)
Non-proximal humerus	124 (79%)	122 (80%)
Distal Radius	57	53
Distal Tibia	27	22
Distal Femur	19	27
Proximal Tibia	9	9
Ulnar	4	5
Other	8	6