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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Dev Biol. 2021 Mar 20;476:1–10. doi: 10.1016/j.ydbio.2021.03.011

Figure 1. Hand1 neural crest cell loss-of-function leads to a low penetrance of ventricular septal defects.

Figure 1.

Whole mount preparations (A-D) and hematoxylin and eosin-stained (E-H) E16.5 hearts and aortic arches in which SHF- (B and F), NCC- (C and G), or both SHF and NCC-specific (D and H) Hand1 has been conditionally ablated reveals rare aortic arch patterning defects (C), and a low penetrance of VSDs (G and H, arrowheads) in NCC Hand1 conditional knockouts. Aortic arches are schematized in A-D. Scale bars = 250 mm. Arrowhead, VSD; Asterisk, PTA; Ao, aorta; LA, left atrium; LCC, left common carotid; LSA, left subclavian artery; LV, left ventricle; RA, right atrium; RCC, right common carotid; RSA, right subclavian artery; RV, right ventricle. (E’-H’) Higher magnification images of E-H to better show structures.