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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Dev Biol. 2021 Mar 20;476:1–10. doi: 10.1016/j.ydbio.2021.03.011

Figure 4. Hand1;Hand2 genetic interaction in the second heart field.

Figure 4.

E16.5 hearts in which Hand1 has been ablated and Hand2 function has been reduced by half within the SHF (Hand1fx/fx;Hand2fx/+;Mef2c-AHF-Cre(+)) display a low penetrance of VSDs (B, arrowhead; summarized in Table 3). Coronal sections have been stained with Sirius Red and Fast Green. Scale bars = 250 μm. Ao, aorta; LA, left atrium; RA, right atrium; LV, left ventricle; RV, right ventricle.