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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Dev Biol. 2021 Mar 20;476:1–10. doi: 10.1016/j.ydbio.2021.03.011

Table 1.

Congenital heart defects in OFT Hand1 mutants.

Genotype n AoRSA membranous
VSD
ASD Phenotypically
Normal
Hand1+/+; Wnt1-Cre(+); Mef2c-AHF-Cre(+) 6 0 (0%) 0 (0%) 0 (0%) 6 (100%)
Hand1−/fx; Mef2c-AHF-Cre(+) 5 0 (0%) 0 (0%) 0 (0%) 5 (100%)
Hand1−/fx; Wnt1-Cre(+) 9 1 (11.1%) 3 (33.3%) 0 (0%) 6 (66.6%)
Hand1−/fx; Wnt1-Cre(+); Mef2c-AHF-Cre(+) 4 0 (0%) 2 (50.0%) 1 (25.0%) 2 (50.0%)

AoRSA, aberrant origin of the right subclavian artery; VSD, ventricular septal defect; ASD, atrial septal defect