Table 7.
Relationship between LEP and LEPR gene polymorphisms and expression of estrogen (ER), progesterone (PR) and epidermal growth factor (HER2) receptors
| Gen SNP |
Genotype | ER+ (%) | ER− (%) | WW vs. WV, VV | WW, WV vs. VV | W vs. V | PR+ (%) |
PR− (%) |
WW vs. WV, VV | WW, WV vs. VV | W vs. V | HER+ (%) |
HER− (%) |
WW vs. WV, VV | WW, WV vs. VV | W vs. V |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
LEP rs7799039 2548 G>A |
GG | 38 | 17 | p = 0.0591 | p = 1.000 | p = 0.2619 | 39.5 | 17.5 | p = 0.0227 | p = 0.6206 | p = 0.2601 | 26 | 30 | p = 0.8345 | p = 0.6330 | p = 0.5938 |
| GA | 44 | 67 | 41 | 67.5 | 53 | 53 | ||||||||||
| AA | 18 | 17 | 19.5 | 15 | 21 | 17 | ||||||||||
|
LEPR rs1137101 223Gln>Arg |
Gln,Gln | 35 | 42 | p = 0.6431 | p = 0.3511 | p = 1.000 | 35 | 41 | p = 0.5435 | p = 0.5846 | p = 0.8878 | 24.5 | 46.5 | p = 0.0324 | p = 0.1634 | p = 0.0199 |
| Gln,Arg | 51 | 37.5 | 51 | 41 | 51 | 45 | ||||||||||
| Arg,Arg | 14 | 20.5 | 14 | 18 | 24.5 | 8.5 | ||||||||||
|
LEPR rs1137100 109Lys>Arg |
Lys,Lys | 44.5 | 50 | p = 0.6584 | p = 0.6908 | p = 0.6090 | 42 | 56 | p = 0.1734 | p = 0.4597 | p = 0.1353 | 45 | 43 | p = 0.8517 | p = 1.000 | p = 1.000 |
| Lys,Arg | 47 | 45 | 49 | 41 | 45 | 48 | ||||||||||
| Arg,Arg | 8.5 | 5 | 9 | 3 | 10 | 9 |
Bold values denote statistical significance at the p < 0.05 level
ER estrogen receptor, PgR progesterone receptor, HER2 human epidermal growth factor receptor 2, WW wild type homozygous, WV heterozygous, VV polymorphic homozygous