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. 2021 Jun 2;4:658. doi: 10.1038/s42003-021-02175-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, b Immunofluorescence shows overlapping of Tomato⁺ and the expression of Runx2, Osterix, collagen X, MMP13, alkaline phosphatase, cleaved caspase 3 and LepR in POC (E18.5) and SOC (P15) of Lepr-cre; tdTomato mice. Arrowheads indicate the overlapping of Tomato⁺ and the expression of indicated markers. HZ = Hypertrophic zone; POC = Primary ossification center; SOC = Secondary ossification center; ColX=collagen X; ALP = alkaline phosphatase; cleaved Casp 3=cleaved caspase 3. Scale bar, 100 μm.