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. 2021 Jun 2;4:658. doi: 10.1038/s42003-021-02175-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Micro-CT analysis of femur in Lepr-cre; Ppp2r1a ^fl/fl mice and relative WT littermates at P30. a Illustration of areas scanned for cortical and trabecular bone. b left Morphological characteristics of femur cortical bone. b right There is no significant difference in cortical thickness between Lepr-cre; Ppp2r1a ^fl/fl mice and relative WT littermates. c left Morphological characteristics of femur trabecular bone. c right Quantification of micro-CT data on trabecular bone volume fraction (Trabecular Bone Volume / Tissue Volume, %), trabecular thickness (μm), trabecular number (mm⁻¹), trabecular spacing (mm), trabecular structure model index, and bone mineral density (p values represent in number on top of each assessment as determined with Student’s t-test). d left Trabecular bone architecture in WT and Lepr-cre; Ppp2r1a ^fl/fl mice with labeling using software analysis of μCT sections (blue: cortical bone; white: trabecular bone; yellow: fat). d right Comparison of fat volume/bone volume (%) in μCT image analysis of Lepr-cre; Ppp2r1a ^fl/fl and relative WT littermates. n = 3 mice; Data are mean ± s.d. *p < 0.05 as determined with Student’s t-test. ns, not significant.