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. 2021 Jun 2;12:3277. doi: 10.1038/s41467-021-23653-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — a Selected mesoderm clusters: NMP: neuromesodermal progenitors, PSM: presomitic mesoderm, PM: paraxial mesoderm, Interm. Mesoderm: intermediate mesoderm, somites, PhM: pharyngeal mesoderm, heart, hematopoietic prog. (progenitors), endothelium. b–k UMAP plot (top) and spline plot (bottom) representing changes of expression over pseudotime for marker genes of each cluster and subcluster: b Nkx1-2 for NMP, c Tbx6 for posterior presomitic mesoderm (pPSM), d Mesp1 for anterior PSM (aPSM), e Cer1 for the differentiation front, f Meox2 for PM, g Pax9 for somite and pharyngeal mesoderm, h Osr1 for intermediate mesoderm, i Nkx2-5 for heart, j Etv2 for haematoendothelial progenitors, k Tie1 for endothelium.