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. 2021 Jun 2;12:3291. doi: 10.1038/s41467-021-23597-9

Fig. 5. STUB1 knockdown reduces UBE4B-mediated alleviated hTau phenotypes in Drosophila.

Fig. 5

a, b Eye-specific knockdown of Drosophila STUB1 significantly reduced eye size relative to GMR > hTau + hUBE4B flies. N = 5 biologically independent experiments. In the box plots the whiskers represent the 5th to 95th percentile range. c, d Neuronal knockdown of Drosophila STUB1 using Elav-Gal4 in Elav > hTau + hUBE4B flies significantly reduced larval crawling. N = 10 biologically independent experiments. In the box plots the whiskers represent the 5th to 95th percentile range. e, f Neuronal knock down of Drosophila STUB1 using Elav-Gal4 in Elav > hTau + hUBE4B flies significantly reduced synaptic bouton numbers relative to Elav > hTau controls. Scale bar 100 µm. N = 10 biologically independent experiments. In the box plots the whiskers represent the 5th to 95th percentile range. Data are presented as the mean ± s.e.m. Statistical significance was determined with two-tailed Student’s t-test. Statistical source data.