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The most effective PAD-4 inhibitors: commercially available chloroamidine and three 1,2,3-triazole-modified peptidomimetics 8, 14, and 16 (Trabocchi et al., 2015).
| PAD-4 inhibitor | Inhibitory effect on PAD-4 | Chemical structure |
|---|---|---|
| Chloroamidine | 24% for CM = 1 mM 36% for CM = 10 mM |
 |
| (8) | 39% for CM = 1 mM 99% for CM = 10 mM |
 |
| (14) | 41% for CM = 1 mM 99% for CM = 10 mM |
 |
| (16) |
18% for CM = 1 mM 99% for CM = 10 mM |
 |
