Table 1.
The significant GO biological processes and KEGG pathways enriched by DETregRGs.
| ID | Term | p-value | Count | Gene symbol |
|---|---|---|---|---|
| GO-biological processes (top 5) | ||||
| GO:0006954 | Inflammatory response | <0.001 | 13 | LYN, PTGIR, F11R, C3AR1. |
| GO:0031663 | Lipopolysaccharide-mediated signaling | <0.001 | 5 | LYN, CCL5, CD14, TLR2. |
| GO:0007166 | Cell surface receptor signaling | 0.002 | 9 | CD53, CCR1, MARCO, PTPRC. |
| GO:0002755 | MyD88-dependent toll-like receptor signaling | 0.002 | 4 | CD14, TLR5, UBA52, and TLR2 |
| GO:0006935 | Chemotaxis | 0.003 | 6 | CCR1, CCL5, RAC2, C3AR1. |
| KEGG pathway (top 5) | ||||
| hsa04610 | Complement and coagulation cascades | <0.001 | 6 | C3AR1, C1QB, C1QA, CFH. |
| hsa04611 | Platelet activation | 0.002 | 7 | LYN, PTGIR, ITPR2, VAMP8. |
| hsa04062 | Chemokine signaling pathway | 0.002 | 8 | CCR1, HCK, CCL5, CXCR4. |
| hsa04670 | Leukocyte trans-endothelial migration | 0.006 | 6 | CXCR4, F11R, CTNNA1, RAC2. |
| hsa04270 | Vascular smooth muscle contraction | 0.006 | 6 | PTGIR, NPR1, PLA2G2A, ITPR2. |
DETregRGs, differentially expressed regulatory T cell-related genes; GO, gene ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes.