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Learning strengthens specific neuronal connections via synaptic modifications.
(a) A schematic drawing of spines on the apical dendritic arbor of a pyramidal neuron. (b) During learning some existing synapses (magenta) are strengthened and new synapses (blue) are formed, leading to stronger connections between the input axons (not shown) and the pyramidal neuron. (c) Selective weakening of the strengthened and newly formed synapses (green) erases the acquired memory.
