Table 1.
Clinical characteristics of the study population along with mean DEXA osteo-metabolic parameters.
| Overall, N = 40 | Alendronate, N = 25 | Denosumab, N = 15 | p | |
|---|---|---|---|---|
| Age, Mean (SD) | 82.1 (5.8) | 81.4 (6.3) | 83.3 (4.8) | 0.315 |
| Female, N (%) | 35 (87.5) | 22 (88.0) | 13 (86.7) | 0.999 |
| Hip fracture type | 16 (40.0) | 12 (48.0) | 4 (26.7) | 0.317 |
| BMI, Median (IQR) | 22.7 (20.5, 25.6) | 23.4 (20.6, 27.9) | 21.0 (19.4, 23.6) | 0.069 |
| Hand Grip, Median (IQR) | ||||
| Females | 15.70 (10.85, 17.75) | 15.75 (11.10, 17.47) | 15.00 (10.00, 17.80) | 0.785 |
| Males | 22.50 (22.10, 24.30) | 22.50 (19.70, 24.70) | 23.20 (22.65, 23.75) | 0.999 |
| Barthel, Median (IQR) | 90 (75, 100) | 90 (70, 95) | 95 (85, 100) | 0.143 |
| ADL, Median (IQR) | 6 (5, 6) | 6 (6, 6) | 6 (5, 6) | 0.247 |
| IADL, Median (IQR) | 7.0 (3.8, 8.0) | 7.0 (5.0, 8.0) | 7.0 (1.5, 8.0) | 0.597 |
| MNA-SF, Median (IQR) | 12 (9, 13) | 12 (10, 13) | 12 (9, 12.5) | 0.357 |
| CIRS comorbidity, Median (IQR) | 4.0 (2.8, 5.2) | 4.0 (2.0, 5.0) | 4.0 (3.5, 5.5) | 0.977 |
| CIRS severity, Median (IQR) | 1.8 (1.6, 2.1) | 1.8 (1.5, 2.1) | 1.9 (1.7, 2.1) | 0.769 |
| N. of drugs, Median (IQR) | 5.0 (3.0, 7.0) | 5.0 (2.0, 7.0) | 5.0 (4.5, 8.0) | 0.338 |
| <5 | 15 (37.5) | 11 (44.0) | 4 (26.7) | 0.367 |
| 5–7 | 16 (40.0) | 10 (40.0) | 6 (40.0) | |
| 8 or more | 9 (22.5) | 4 (16.0) | 5 (33.3) | |
| SPMSQ Median (IQR) | 1.0 (0.0, 3.0) | 1.0 (0.0, 3.0) | 2.0 (0.0, 3.0) | 0.954 |
| VIT.D 25-OH (ng/ml), Median (IQR) | 15.60 (7.53, 25.45) | 15.40 (6.20, 22.00) | 21.40 (9.45, 26.60) | 0.295 |
| PTH (ng/L) Median (IQR) | 33.50 (25.00, 50.50) | 33.00 (25.00, 48.00) | 35.00 (26.50, 51.50) | 0.557 |
| FN-BMD, Median (IQR) | 0.65 (0.62, 0.73) | 0.66 (0.63, 0.72) | 0.63 (0.59, 0.73) | 0.395 |
| TH-BMD, Median (IQR) | 0.72 (0.65, 0.77) | 0.72 (0.65, 0.77) | 0.72 (0.63, 0.78) | 0.893 |
| LS-BMD, Median (IQR) | 0.96 (0.87, 1.07) | 0.97 (0.88, 1.14) | 0.91 (0.82, 1.03) | 0.235 |
| TBS, Median (IQR) | 1.09 (0.96, 1.18) | 1.07 (0.92, 1.13) | 1.15 (1.06, 1.23) | 0.050 |
| RSMI kg/m2, Median (IQR) | 5.90 (5.12, 6.86) | 6.22 (5.18, 7.02) | 5.76 (5.08, 6.60) | 0.299 |
BMI, body mass index; FN, Femoral neck; LS, Lumbar spine; TH, Total hip; ADL, activities of daily living; IADL, instrumental activities of daily living; CIRS, cumulative illness rating scale; MNA-SF, Mini nutritional assessment; SPMQS, short portable mental status questionnaire; PHT, parathormone; BMD, Bone marrow density; TBS, Trabecular bone score; RSMI, Relative skeletal muscle index.