Table 3.

The detailed results from the pathway analysis.

Pathway name	Hits/Total	Expected	Raw p	–log 10(p)	Holm adjust	Impact
Synthesis and degradation of ketone bodies	1/6	0.069796	0.067866	2.6902	1	0.7
Phenylalanine metabolism	1/45	0.52347	0.41224	0.88614	1	0.11906
Galactose metabolism	2/41	0.47694	0.081006	2.5132	1	0.08543
Fructose and mannose metabolism	1/48	0.55837	0.43291	0.83723	1	0.04372
Butanoate metabolism	1/40	0.46531	0.37618	0.97769	1	0.0403
Propanoate metabolism	2/35	0.40715	0.061325	2.7916	1	0.02848
Glycerophospholipid metabolism	2/39	0.45368	0.074242	2.6004	1	0.02437
Valine, leucine and isoleucine biosynthesis	1/27	0.31408	0.27215	1.3014	1	0.01325
Cysteine and methionine metabolism	1/56	0.65143	0.48465	0.72434	1	0.01289
Purine metabolism	1/92	1.0702	0.66629	0.40603	1	0.00878
Arginine and proline metabolism	1/77	0.89572	0.59972	0.51129	1	0.00645
Phenylalanine, tyrosine and tryptophan biosynthesis	1/27	0.31408	0.27215	1.3014	1	0.00062
Valine, leucine and isoleucine degradation	2/40	0.46531	0.0776	2.5562	1	0
D-Glutamine and D-glutamate metabolism	1/11	0.12796	0.12101	2.1119	1	0
Aminoacyl-tRNA biosynthesis	2/75	0.87246	0.21633	1.5309	1	0
Pantothenate and CoA biosynthesis	1/27	0.31408	0.27215	1.3014	1	0
Nitrogen metabolism	1/39	0.45368	0.36872	0.99773	1	0
Glycine, serine and threonine metabolism	1/48	0.55837	0.43291	0.83723	1	0
Starch and sucrose metabolism	1/50	0.58164	0.44629	0.80678	1	0
Tyrosine metabolism	1/76	0.88409	0.59485	0.51944	1	0

The “Total” is the total number of metabolites in each pathway; The “Hits” is the actually matched number according to the uploaded data; The “Raw p” is the original P-value calculated from enrichment analysis; The “Holm adjust” is the p-value adjusted by Holm-Bonferroni method and the “Impact” is the pathway impact value calculated from pathway topology analysis.