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. 2021 May 20;15:619160. doi: 10.3389/fnint.2021.619160

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Copyright © 2021 Zou, Tian and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Synaptic vesicle endocytosis dysfunction potentially mediate dopaminergic neurodegeneration through intersections with various pathway. Mutations in the PD-related genes or SVE-related genes reviewed in this article may cause damage to the endocytosis of vesicles at the terminal axons of neurons. SVE may interact with synaptic transmission, autophagy and mitochondrial autophagy, and the endolysosomal system has the effect of this two-way condition. These pathways can lead to the accumulation and spread of misfolded proteins with axon degeneration or neurotoxicity, and ultimately lead to the pathogenesis of PD. Among them, regarding the relationship between SVE and lipid raft synthesis and metabolism, the mechanism of abnormal lipid raft metabolism leading to the pathogenesis of PD deserves more research and attention. PD, Parkinson’s disease; SVE, synaptic vesicle endocytosis.