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Chromosome aberrations and driver mutated genes in uveal melanoma and their prognostic implications
| Genetic features | Clinical implications |
|---|---|
| Non-random chromosome aberrations | |
| Monosomy 3, gain of chromosome 8q | High metastatic risk |
| Gain of chromosome 6p | Low metastatic risk |
| Driver genes (mutations) | |
| BAP1 | High metastatic risk, poor survival |
| EIF1AX | Increased patient survival |
| SF3B1 | Late-onset metastatic disease |
| GNA11, GNAQ | No prognostic value, not linked to patient outcomes |
