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. 2021 Jun 2;5:46. doi: 10.1038/s41698-021-00186-z

Fig. 5. Comparisons of DNA methylation profiles between the three GC subtypes in TCGA-STAD.

Fig. 5

a The EMT-promoting, EMT-inhibiting, and DNA mismatch repair genes displaying significantly different methylation levels between the three GC subtypes. The one-tailed Mann–Whitney U test P values are indicated. b Correlations between expression levels and methylation levels of the genes whose methylation levels are significantly different between the three GC subtypes. c 17 CpG sites within MLH1 CpG islands having significantly lower methylation levels in StE than ImD and ImE. The methylation levels (average β values) are shown. d Spearman correlations between MLH1 expression levels and the methylation levels of its 17 CpG sites, which have significantly lower methylation levels in StE than ImD and ImE. e Spearman correlations between TMB and MLH1 methylation levels and expression levels. *P < 0.05, **P < 0.01, ***P < 0.001.