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. 2021 Jun 2;11:11595. doi: 10.1038/s41598-021-89934-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of mitochondrial genes predict survival in ovarian cancer patients. (A) Kaplan Meier Plotter (KMPlot.org) survival analysis of patients with ovarian cancer exhibiting low (n = 454) or high (n = 160) gene expression for a key component of mitochondrial metabolism, the mitochondrial pyruvate carrier 2 (MPC2) gene. (B) Hazard ratios (HR) from Kaplan Meier survival analysis shown as forest plots for genes encoding subunits of the mitochondrial respiratory chain complexes I, (C) II, (D) III, (E) IV, (F) V, and (G) and mtDNA-related genes. (H) Summary of results illustrating the proportion of significant subunits in previous analysis relative to results from a randomly selected group of 200 genes. Shown are mean HR with 95% C.I. established based on the optimal cutoff; n = 614–1435 for each gene. Filled symbols are significant based on the 95% C.I.