Table 1.
Comparison of clinical characteristics between patients with D-dimer ≤ 0.7 mg/L and > 0.7 mg/L.
| Characteristic | All patients (N = 86) | D-dimer ≤ 0.70 mg/L (N = 44) | D-dimer > 0.70 mg/L (N = 42) | P value |
|---|---|---|---|---|
| Age, yrs | 61.0 (47.0–68.8) | 51.0 (42.5–63.0) | 67.0 (60.2–73.8) | < 0.001 |
| Female, n (%) | 50 (58.1%) | 24 (54.5%) | 26 (61.9%) | 0.636 |
| Coexisting illnesses | ||||
| Hypertension, n (%) | 18 (20.9%) | 4 (9.1%) | 14 (33.3%) | 0.013 |
| Diabetes, n (%) | 4 (4.7%) | 2 (4.5%) | 2 (4.8%) | 1.000 |
| IHD, n (%) | 1 (1.2%) | 1 (2.3%) | 0 (0.0%) | 1.000 |
| COPD, n (%) | 4 (4.7%) | 2 (4.5%) | 2 (4.8%) | 1.000 |
| Cancer | 3 (3.5%) | 1 (2.3%) | 2 (4.8%) | 0.612 |
| Vital signs | ||||
| Temperature, °C | 36.5 (36.4–36.7) | 36.5 (36.4–36.6) | 36.5 (36.4–36.7) | 0.409 |
| Respiratory rate, per min | 20.0 (18.0–21.0) | 20.0 (18.0–21.0) | 20.0 (18.0–21.0) | 0.308 |
| Heart rates, beats per min | 86.0 (78.0–96.0) | 90.0 (78.0–98.0) | 82.0 (78.0–94.0) | 0.295 |
| SBP, mmHg | 128.0 (120.0–136.0) | 122.0 (113.0–132.0) | 131.0 (124.0–142.2) | 0.003 |
| DBP, mmHg | 78.0 (73.0–83.0) | 76.0 (72.0–80.0) | 80.0 (75.0–87.0) | 0.058 |
| Laboratory findings | ||||
| White cell count, per mm3 | 5.300 (4.135–6.537) | 5.075 (3.748–5.938) | 6.075 (4.598–7.282) | 0.006 |
| Hemoglobin, g/liter | 124.0 (114.0–135.5) | 125.0 (115.0–138.0) | 120.0 (110.2–131.8) | 0.105 |
| Hematocrit | 0.36 (0.32–0.39) | 0.37 (0.35–0.40) | 0.34 (0.32–0.38) | 0.030 |
| Platelet count, per mm3 | 234,000 (172,500–282,750) | 234,000 (169,500–272,250) | 234,500 (184,750–289,750) | 0.473 |
| D-dimer | 0.70 (0.35–1.76) | 0.36 (0.26–0.46) | 1.78 (1.17–4.40) | < 0.001 |
| CD4 + cell | 452 (263–586) | 449 (350–568) | 488 (229–589) | 0.718 |
| CD8 + cell | 244 (154–380) | 290 (197–434) | 209 (93–340) | 0.016 |
| Creatinine, μmol/liter | 59.5 (48.0–70.8) | 60.5 (49.5–72.0) | 58.5 (47.0–69.0) | 0.595 |
| ALT, U/liter | 22.0 (15.0–37.8) | 22.5 (16.5–39.2) | 21.0 (15.0–30.2) | 0.675 |
| AST, U/liter | 24.0 (18.0–34.0) | 24.5 (17.8–31.2) | 23.5 (18.2–37.8) | 0.653 |
| Albumin, g/liter | 37.7 (34.741.0) | 39.8 (37.8–42.0) | 35.4 (32.2–37.5) | < 0.001 |
| Sodium, mEq/L | 142.0 (138.0–145.0) | 142.0 (140.0–144.2) | 142.0 (137.2–145.0) | 0.742 |
| Procalcitonin, ng/mL | 0.04 (0.03–0.07) | 0.04 (0.03–0.06) | 0.05 (0.03–0.09) | 0.277 |
| CRP, mg/liter | 11.5 (5.0–46.6) | 5.6 (5.0–29.8) | 35.8 (5.0–95.6) | 0.017 |
| CK-MB, U/liter | 1.0 (0.6–1.4) | 0.9 (0.6–1.2) | 1.1 (0.9–1.8) | 0.005 |
| hs-cTnI > 99th percentile URL | 8 (9.4%) | 3 (7.0%) | 5 (11.9%) | 0.483 |
| NT-proBNP, pg/ml | 88.0 (30.9–248.9) | 32.6 (18.0–91.9) | 200.4 (91.6–380.8) | < 0.001 |
| NT-proBNP > 300 pg/ml | 20 (23.3%) | 4 (9.1%) | 16 (38.1%) | 0.003 |
| Oxygen therapy, n (%) | 51 (59.3%) | 20 (45.5%) | 31 (73.8%) | 0.009 |
| High-flow nasal cannula | 2 (2.3%) | 1 (2.3%) | 1 (2.4) | 1.000 |
| Non-invasive respiratory support | 3 (3.5%) | 0 (0%) | 3 (7.1%) | 0.112 |
| Invasive respiratory support | 1 (1.2%) | 0 (0%) | 1 (2.4%) | 0.488 |
| Saturaion, %# | 97 .0 (96.0–99.0) | 97.5 (96.0–99.0) | 97.0 (96.0–99.0) | 0.318 |
| Oxygenation index* | 308.1 (224.2–376.0) | 337.3 (292.4–385.4) | 273.2 (202.4–332.4) | 0.047 |
| Oxygenation index < 300* | 24 (45.3%) | 5 (25.0%) | 19 (57.6%) | 0.043 |
Data are expressed as median (interquartile range) or counts and percentage, as appropriate.
IHD Ischemic heart disease, COPD Chronic obstructive pulmonary disease, SBP Systolic blood pressure, DBP Diastolic blood pressure, ALT Alanine aminotransferase, AST Aspartate aminotransferase, CRP C-reactive protein, CK-MB Creative kinase MB, hs-cTnI high-sensitivity cardiac troponin I, URL upper reference limit, NT-proBNP N-terminal pro-B-type natriuretic peptide.
#There were 28 patients in the group of D-dimer ≤ 0.70 mg/L and 33 patients in D-dimer > 0.70 mg/L had the data of Saturation.
*There were 19 patients in the group of D-dimer ≤ 0.70 mg/L and 31 patients in D-dimer > 0.70 mg/L had the data of oxygenation.