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. 2021 Jun 2;4:665. doi: 10.1038/s42003-021-02192-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a–c Typical examples of the capacitive current transients were recorded under voltage-clamp condition at a holding potential of −50 mV following a hyperpolarized voltage pulse according to the protocols indicated above each trace in Kis (a) and AcerKis (c) neurons. (b) represents the reduced equivalent circuit of the neuron cell body plasma membrane obtained by combining a fixed capacitance (Cm) in parallel with ion-specific pathway (Rm). The decay phase of the transient was well-fitted with a single exponential in Kis neurons whereas two exponential functions were used to fit the decay phase of the transient in AcerKis neurons giving fast and slow time constants (see text for details). d The corresponding comparative histogram illustrates the mean values of the time constants calculated for Kis and AcerKis neurons. Bars represent mean ± S.E.M. (n = 9–10). The number of experiments (n) are biologically independent samples.