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. 2021 Jun 2;4:665. doi: 10.1038/s42003-021-02192-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a, b Voltage-dependence of steady-state inactivation and conductance parameters of the voltage-gated inward sodium current in Kis (a, n = 7–8) and KdrKis (b, n = 4–6) neurons. Data points are mean values ± S.E.M. Smooth curves were fitted through the data points using Boltzmann distributions (see Eqs. 8 and 9 for normalized conductance and inactivation, respectively). c Enlarged colored areas indicate overlap between activation and inactivation curves for Kis (blue) and KdrKis (orange) neurons, which is expected to result in a window current; this window current being largest for KdrKis voltage-gated sodium channels. d Comparative histogram illustrating the values of the resting membrane potential recorded under current-clamp condition in Kis and KdrKis neurons. Bars represent mean ± S.E.M. (n = 8 and n = 4 for Kis and KdrKis neurons, respectively). The statistical test used was Student unpaired t-test, **p < 0.01. e Voltage-dependent steady-state inactivation of the voltage-gated calcium current studied with the two-pulse voltage-clamp protocol (see text for details) in Kis (n = 7) and KdrKis (n = 4) neurons. Smooth curves of inactivation were fitted through data points using Boltzmann distribution (Eq. 9). Data are mean ± S.E.M. In all cases, the number of experiments (n) are biologically independent samples.