Skip to main content
. 2021 Jun 2;4:660. doi: 10.1038/s42003-021-02201-2

Fig. 4. The dynamic reorganization of the mammary gland through the development, pregnancy, and HRT, and its implication for the risk of specific breast cancer subtypes.

Fig. 4

a PAM50 molecular subtyping classification at single-cell resolution in the human and mouse mammary gland visualized on the UMAP dimensionality. b, c The mammary gland development and reorganization through the different life stages (b) and pregnancy (c). The cells from each stage are plotted in red on the UMAP dimensionality and stream plots. Five thousand cells were sampled from the entire data for background UMAP visualization. The proportion of each cluster in the mammary epithelium is summarized in the stacked bar plot. d The mammary gland reorganization during menopausal HRT and exposure to the PBDEs. The changes in proportion of each cluster in the entire gland are summarized.