Table 1.
Mucosal pathogens that require Th17-mediated protection.
| Pathogen | Natural Infection Cell-mediated Protection | Vaccine Induced Cell-mediated Response | References |
|---|---|---|---|
| Bordetella pertussis | Th1 and Th17 | Th1 (whole cell), Th2 (acellular) | 180,181 |
| Candida albicans | Th1 and Th17 | No vaccine | 182 |
| Yersinia pestis | Th1 and Th17 (Attenuated strain) | No vaccine | 183 |
| Adenovirus Vector | Th1 and Th17 | N/A | 184 |
| Mycobacterium tuberculosis | Th1 and Th17 | Th1, Th17, *Th2, *Treg *associated with poor outcomes | 185 |
| Helicobactor pylori | Th17 | No vaccine | 4,186 |
| Influenza virus | Th1 and Th17 | Th1 | 4,187 |
| Pseudomonas aeruginosa | Th17 | No vaccine | 4,188 |
| Streptococcus pneumonia | Th17 | No vaccine | 4,189 |
| Klebsiella pneumoniae | Th17 | No vaccine | 4,20 |
| Aspergillus fumigatus | Th17 | No vaccine | 4,190 |
| Blastomyces dermatitidis | Th17 | No vaccine | 4,191 |
| C. posodasii | Th17 | No vaccine | 4,191 |
| H. Capsulatum | Th17 | No vaccine | 4 |
| Herpes Simplex Virus | Th17 | No vaccine | 192 |
| HIV | Reduced Th17 compartment associated with poor viral control | No vaccine | 193 |
List of pathogens that have been shown to elicit natural immune protection with induction of Th17-memory response. Included are vaccines currently available and the T-cell mediated response associated with protection.