Table 1.

Summary statistics for the 13 independently genome-wide significant variants from the meta-analysis (N = 47,736).

Variant ID	Chr	Position (Hg38)	Effect allele	Other allele	Effect-allele frequency	Gene	Variant type	Combined effect	95% CI	Comb. P-value
rs1061170	1	196690107	C	T	0.39	CFH	Missense	0.048	0.034, 0.062	2.79 × 10−11
rs3828323	2	159951564	C	T	0.48	PLA2R1	Missense	0.118	0.104, 0.132	7.50 × 10−65
rs114821641	2	159858447	T	C	0.003	LY75	Stop gained	0.400	0.294, 0.506	1.08 × 10−13
rs755902185	2	159864896	A	AC	0.0004	LY75	Frameshift	0.445	0.302, 0.588	1.05 × 10−9
rs71311394	3	98793766	G	A	0.06	ST3GAL6	3 Prime UTR	0.137	0.112, 0.162	5.31 × 10−26
rs200185927	6	32449458	A	AAAGAAGAAAG	0.25	HLA-DRA	Downstream	0.060	0.043, 0.077	2.58 × 10−12
rs75179845	9	133257567	C	T	0.10	ABO	Intron	0.148	0.121, 0.175	8.37 × 10−27
rs2227566	10	73913973	C	T	0.46	PLAU	Splice region	−0.124	−0.138, −0.110	1.36 × 10−70
rs7952602	11	126363774	C	G	0.14	ST3GAL4	Intron	−0.131	−0.152, −0.110	2.33 × 10−34
rs758641530	17	7176936	C	CCCCCAGCCCCAG	0.004	ASGR1	Intron	1.089	1.002, 1.176	1.66 × 10−132
rs34392939	18	27113190	GAAA	GAA	0.30	CHST9	Intron	−0.065	−0.080, −0.050	1.58 × 10−18
rs36229204	19	43671830	T	C	0.03	PLAUR	Upstream	−0.270	−0.306, −0.234	3.55 × 10−48
rs601338	19	48703417	G	A	0.55	FUT2	Stop gained	−0.046	−0.060, −0.032	7.21 × 10−11

Effect estimate in units of standard deviation per copy increment in the effect allele.

Allele frequencies reported are based on European populations (Supplementary Data 1 reports the cohorts-specific effect allele frequencies).

Table is ordered by genomic locus. Full table available in Supplementary Data 1.