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. 2021 Jun 2;6:79. doi: 10.1038/s41541-021-00342-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Heavy chain variable region germline gene distribution of gHgL mAbs in the six subjects (black bars), compared to the naive variable region gene repertoire (red bars). b The kappa chain variable region germline gene distribution of gHgL mAbs in the six subjects (black bars), compared with the naive variable region gene repertoire (red bars). c Heatmap frequency of V-gene usage of the paired gHgL antibodies. d The pie chart of antibody variable region gene germline distribution in each subject for the gHgL antibodies. Red color indicates the HV1-18 germline, and the KV1-5 germline. The numbers of antibodies of each subject are shown in the middle of the pie. The percentage of HV1-18, and KV1-5 germline are indicated. e Heavy chain variable region gene germline distribution of the pentamer-specific mAbs in the six subjects (black bars), compared to the naive variable region gene repertoire (red bars). f Heatmap frequency of V-gene usage of the paired antibodies to pentamer. g The light-chain pairing preference of mAbs to different HCMV antigens. The reference naive antibody variable region gene repertoire is from a previous study³⁶.