Table 1.

Size (radius) and polydispersity percentage (Pd %) of the control and Tf-PEG liposomes following the 3rd and 6th LFUS pulses. Results are the average of three batches.

	Before sonication	After 3rd pulse			After the 6th pulse
		6.2 mW/cm2	9 mW/cm2	10 mW/cm2	6.2 mW/cm2	9 mW/cm2	10 mW/cm2
Control
Radius (nm)	87.5 ± 2.57	73.7 ± 1.14	70.8 ± 0.424	70.7 ± 1.71	66.3 ± 2.18	62.1 ± 1.58	57.2 ± 1.23
p-value		0.226	0.000387	0.000417	0.000574	0.000147	5.02 × 10–5
Pd (%)	14.1 ± 2.95	16.6 ± 0.759	16.9 ± 1.21	15.3 ± 5.61	19.8 ± 2.90	21.8 ± 2.05	22.4 ± 1.05
p-value		0.198	0.233	0.210	0.0424	0.00768	0.0120
Tf-PEG
Radius (nm)	80.5 ± 1.89	77.1 ± 1.25	76.4 ± 2.15	73.0 ± 1.25	74.1 ± 1.79	71.6 ± 2.04	69.7 ± 4.68
p-value		0.0366	0.0460	0.000579	0.000611	0.00136	0.01125
Pd (%)	9.1 ± 2.70	16.3 ± 3.88	18.6 ± 1.61	20.2 ± 2.10	21.3 ± 2.19	23.7 ± 0.063	23.9 ± 0.23
p-value		0.0364	0.00115	0.000637	0.000103	3.75 × 10–5	3.45 × 10–5