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. 2021 May 20;12:652623. doi: 10.3389/fgene.2021.652623

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Copyright © 2021 Jeong, Lim, Lee, Oh, Cho, Seong, Jung and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Examination of transcription factor (TF) cooperation. High score of B_p and C_p represents the amount of cooperativity of co-working TFs in the pathways. Heatmap in the left panel shows the cooperation in terms of pathway enrichment over time in high-fat meal (HFM). Pathway enrichment in the G_all was compared to the simulations given each TF (G_i) and measured using Equation (5). Heatmap in the right panel shows the cooperative potential using enriched pathway genes. Betweenness centrality was compared between G_all and G_i using Equation (6).