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. 2021 Jun 2;6:42. doi: 10.1038/s41525-021-00201-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Hemibrain and cortical tissues were extracted from two-week-old (P14) and six-week-old (P40) Pten^m3m4/m3m4 male mice (N = 3) for preparation for RNA sequencing, proteomic scanning, and pS/pT and pY phosphoproteomic scanning. After –omic profiling, these data were analyzed through various bioinformatics approaches. B Volcano plot of differentially expressed protein assessed at P14 (left) and P40 (right) by proteomic scan. C Volcano plot of differentially phosphorylated proteins assessed at P14 (left) and P40 (right) by phosphoproteomic scan.