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. 2021 Jun 2;6:42. doi: 10.1038/s41525-021-00201-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A The top five most significant “Canonical Pathways” identified by IPA core analysis in the P40 cortical and P14 hemibrain proteome comparing Pten^m3m4/m3m4 mice to wildtype controls. B The top five most significant “Canonical Pathways” identified by IPA core analysis in the P40 cortical and P14 hemibrain phosphoproteome comparing Pten^m3m4/m3m4 mice to wildtype controls. C The top two “disease and bio function” networks (by size) identified by IPA core analysis from the P40 cortical proteome of Pten^m3m4/m3m4 mice compared to wildtype controls with activity prediction overlaid. Green = decreased expression. Red = increased expression. Color intensity = degree of increased/decreased expression. Hashed line = indirect biological relationship. Arrow = Direction of relationship. Orange = predicted activation. Yellow = observation inconsistent with direction of prediction. Gray = no influence on prediction. D The top two “disease and bio function” networks (by size) identified by IPA core analysis from the P40 cortical phosphoproteome of Pten^m3m4/m3m4 mice compared to wildtype controls with activity prediction overlaid. Green = decreased phosphorylation. Red = increased phosphorylation. Color intensity = degree of increased/decreased phosphorylation. Hashed line = indirect biological relationship. Arrow = Direction of relationship. Orange = predicted activation. Yellow = observation inconsistent with direction of prediction. Gray = no influence on prediction. E The top network identified by IPA from among the differentially expressed proteins with Molecular Activity Predictor (MAP) results overlaid. The network is organized hierarchically, meaning the most important regulatory molecule is placed on top. Green = decreased expression. Red = increased expression. Color intensity = degree of increased/decreased expression. Solid line = direct biological relationship. Hashed line = indirect biological relationship. Arrow = direction of relationship. Orange = predicted activation. Blue = predicted inactivation. Yellow = observation inconsistent with the direction of prediction. Gray = no influence on prediction.