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. 2021 Jun 2;12:3281. doi: 10.1038/s41467-021-23531-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Discrete generation model of a SPECIES-like extreme underdominant system released at 60% in population A and initially absent from population B. Population A exchanges migrants with population B at a rate of 1% per individual per generation. For a fitness cost of 10%, the system reaches near-fixation in population A within seven generations but only spreads to 0.01% in population B. b As the migration rate increases, the SPECIES system reaches a higher frequency in population B, exceeding 4%; however, for migration rates above 16.6% per individual per generation, it is eliminated from both populations through dilution of population A with wild types from population B. c For the two-population model, there is a migration threshold below which the construct fixes in population A and persists at a low level in population B and above which it is lost in both populations. For the source model, extreme underdominance displays threshold behavior with respect to migration rate. d Discrete generation model of reciprocal chromosomal translocations released at 60% in population A and initially absent from population B. Population A exchanges migrants with population B at a rate of 1% per individual per generation. For a fitness cost of 10%, the system reaches near-fixation in population A within 22 generations and spreads to 3.6% in population B. e As the migration rate increases, the translocations reach a higher frequency in population B, exceeding 15%; however, for migration rates above 5.0% per individual per generation, they are eliminated from both populations through dilution of population A with wild types from population B. f For the two-population model, there is a migration threshold below which translocations fix in population A and persist at a low level in population B, and above which they are lost in both populations. For the source model, translocations display threshold behavior with respect to migration rate. g Discrete generation model of two-locus engineered underdominance released at 60% in population A and initially absent from population B. Population A exchanges migrants with population B at a rate of 1% per individual per generation. For a fitness cost of 10%, the system reaches near-fixation in population A within eight generations and spreads to 3.2% in population B. h As the migration rate increases, the system reaches a higher frequency in population B, exceeding 21.2%; however, for migration rates above 4.2% per individual per generation, the system becomes fixed in both populations. i Two-locus engineered underdominance displays threshold behavior with respect to migration rate.