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. 2021 May 20;12:616719. doi: 10.3389/fphar.2021.616719

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Copyright © 2021 Hanaoka, Kikuchi, Kaneko, Seki, Tsujimoto, Chiba and Takeuchi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of magnesium level and fraction excretion of magnesium by drug. All patients were divided into four groups according to TAC and PPI use. (A) Comparison of serum Mg levels among the four groups. The dotted line indicates the normal limit of the magnesium level (1.8 mg/dl). (B) Comparison of FEMg in patients with hypomagnesemia (n = 57). The dotted line indicates the normal limit of FEMg (2.0%). TAC, tacrolimus; PPI, proton pump inhibitor; Mg, magnesium; FEMg, fractional excretion of magnesium.