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. 2021 May 20;12:616719. doi: 10.3389/fphar.2021.616719

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Copyright © 2021 Hanaoka, Kikuchi, Kaneko, Seki, Tsujimoto, Chiba and Takeuchi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Associations between tacrolimus concentration and magnesium level and tacrolimus concentration and fractional excretion of magnesium by drug. In patients not using PPIs, TAC concentration was significantly correlated with Mg level (r = −0.61, p < 0.01) (A) and FEMg (r = 0.38, p = 0.05) (B). In patients treated with both TAC and PPIs, no association was observed between TAC concentration and Mg level (r = 0.25, p = 0.19) (C) or FEMg (r = -0.07, p = 0.73) (D). PPI, proton pump inhibitor; TAC, tacrolimus; Mg, magnesium; FEMg, fractional excretion of magnesium.