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. 2021 May 20;8:691208. doi: 10.3389/fmolb.2021.691208

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Copyright © 2021 Redzic, Duff, Blue, Pitts, Agarwal and Eisenmesser.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evolution and mutagenesis “dial” dynamics and function in BLVRB. (A) R2-CPMG dispersion profiles are shown for human BLVRB WT (black) and lemur BLVRB WT (magenta) along with human BLVRB WT and human BLVRB T164S (blue). (B) Amides that exhibit changes to their R2-CPMG dispersion profiles (blue spheres) are shown together with residues differences between human and lemur BLVRB homologues (magenta). (C) Steady-state kinetics of human WT BLVRB, lemur WT BLVRB, and human BLVRB T164S.