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. 2021 May 20;12:591623. doi: 10.3389/fgene.2021.591623

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Copyright © 2021 Pu, Zhu, Wang, Zhong, Peng and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The construction of hub gene associated with ceRNA network based on analysis of protein to protein interaction (PPI) network. The PPI network of DEGs (A). PPI network of 6 hub genes, the color of nodes from red to yellow indicates that the connected degrees between each molecule with others decrease gradually (B). the hub gene ceRNA regulatory network including 3 DEMs (rectangle) and 6 hub DEGs (ellipse) as well as 46 lncRNA (diamond) (C).