TABLE 2.

The correlation between six hub genes and gene markers of monocyte and macrophages in HCC from GEPIA.

Immune cell type		Gene marker	CEP55		CLSPN		DEPDC1		KIF23		MYBL2		RACGAP1
			R	P	R	P	R	P	R	P	R	P	R	P
Tumor	Monocyte	CD86	0.53	*	0.44	*	0.3	****	0.52	*	0.25	****	0.38	****
		CSF1R	0.44	*	0.35	****	0.22	****	0.45	*	0.15	**	0.29	****
	TAM	CD68	0.33	****	0.3	****	0.18	***	0.33	****	0.2	***	0.27	****
		IL10	0.57	*	0.29	****	0.18	***	0.34	****	0.12	*	0.35	****
	M1 Macrophage	IRF5	0.34	****	0.35	****	0.27	****	0.34	****	0.36	****	0.38	****
		PTGS2	0.066	0.21	0.12	*	0.1	*	0.089	0.088	-0.013	0.8	0.048	0.36
	M2 Macrophage	CD163	0.46	*	0.26	****	0.16	**	0.43	*	0.13	*	0.24	****
		VSIG4	0.46	*	0.32	****	0.21	****	0.49	*	0.15	**	0.26	****
		MS4A4A	0.41	*	0.26	****	0.16	**	0.39	****	0.092	0.079	0.23	****
Normal	Monocyte	CD86	0.43	**	0.17	0.24	0.13	0.38	0.42	**	0.3	*	0.35	*
		CSF1R	0.41	**	0.26	0.064	0.1	0.48	0.53	****	0.33	*	0.42	**
	TAM	CD68	0.34	*	0.17	0.24	0.026	0.86	0.42	**	0.3	*	0.36	**
		IL10	0.25	0.07	0.1	0.47	0.02	0.89	0.19	0.2	0.15	0.3	0.36	*
	M1 Macrophage	IRF5	0.29	0.1	0.051	0.73	0.043	0.77	0.24	0.093	0.15	0.29	0.23	0.11
		PTGS2	0.02	0.89	-0.033	0.82	-0.098	0.5	0.064	0.66	0.00029	1	0.049	0.73
	M2 Macrophage	CD163	0.36	*	0.13	0.38	0.013	0.93	0.44	**	0.27	0.058	0.28	*
		VSIG4	0.2	0.15	0.097	0.5	0.00088	1	0.38	**	0.2	0.15	0.24	0.099
		MS4A4A	0.37	**	0.14	0.34	0.078	0.59	0.46	***	27	0.055	0.38	**

Annotation: Tumor, correlation analysis in HCC tissue of TCGA. Normal, correlation analysis in normal liver tissue of TCGA. R, R-value of Pearson’s correlation. *P < 0.05; **P < 0.01; ***P < 0.001; and ****P < 0.0001.