TABLE 3.

The predicted compounds target hub genes via Drugbank database.

Hub genes	Predicted compounds	Accession number	Type	Classification in database	Chemical formula	Numbers of Clinical trial
CEP55	Irdabisant	DB12900	small molecule	Investigational	C18H23N3O2	1
	CEP-9722	DB14882	small molecule	Investigational	C24H26N4O3	3
	CEP-1347	DB05403	small molecule	Investigational	C33H33N3O5S2	1
	CEP-37440	DB13060	small molecule	Investigational	C30H38ClN7O3	1
	Cefapirin	DB01139	small molecule	Approved	C17H17N3O6S2	Not available
CLSPN	Calfactant	DB06415	small molecule	Approved	not found	13
	Calusterone	DB01564	small molecule	Experimental	C21H32O2	Not available
MYBL2	Clotrimazole	DB00257	small molecule	Approved	C22H17ClN2	37
	Propafenone	DB01182	small molecule	Approved	C21H27NO3	22
	Letrozole	DB01006	small molecule	Approved, Investigational	C17H11N5	308
	Sildenafil	DB00203	small molecule	Approved, Investigational	C22H30N6O4S	290
	Ranitidine	DB00863	small molecule	Approved, Withdrawn	C13H22N4O3S	51
	Valproic acid	DB00313	small molecule	Approved, Investigational	C8H16O2	244
	Esomeprazole	DB00736	small molecule	Approved, Investigational	C17H19N3O3S	245
	Pregabalin	DB00230	small molecule	Approved, Investigational	C8H17NO2	306

No compounds were detected in Drugbank database for hub genes of DEPDC1, KIF23, and RAGCAP1.